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Tuesday, December 17, 2013

Opening Remarks

Dr. Linda Porter, Office of Pain Policy, NINDS, opened the meeting.

News: Proposed Initiative for Overlapping Pain Conditions

Drs. John Kusiak (NIDCR) and Linda Porter (NINDS) presented a proposal for a funding opportunity announcement (FOA) for chronic overlapping pain conditions. Dr. Kusiak presented a preliminary draft of the FOA, which will be considered for release as a program announcement (PA). The overarching theme and objectives address the recommendations of a workshop on overlapping pain conditions, sponsored by the NIH and held in October of 2012. The PA will take advantage of NIH’s ongoing projects, such as Orofacial Pain: Prospective Evaluation and Risk Assessment and Multi-disciplinary Approach to the Study of Chronic Pelvic Pain (MAPP), and encourage research that will increase the understanding of the etiology and assessment of multiple chronic pain conditions. Following Dr. Kusiak’s presentation, PC representatives discussed the proposed PA, provided initial input on the proposal, and will have further opportunity to send more detailed feedback as the process moves forward.

News: Pharmacogenetics and Opioid Analgesics

Dr. Nora Volkow, Director, NIDA, provided an overview of a recent presentation from Purdue Pharma, LP. She also reported that the FDA will be requiring pharmaceutical companies to conduct post-market studies of potential adverse effects, such as abuse, addiction, etc., associated with opioids used in the treatment of pain. This research effort would continue through 2018. Dr. Volkow indicated that this may provide an opportunity to perform a targeted pharmacogenetics study and noted that input from Dr. Eric Green, Director, NHGRI, would be valuable. Further, Dr. Dave Thomas (NIDA) has been working with the FDA and various pharmaceutical companies on this matter, and he discussed the project in more detail. There was an interest expressed by Dr. Story Landis and others of the Pain Consortium in participating with this effort.  

News: Pain Portfolio Database

Dr. Tara Schwetz, Office of Pain Policy, NINDS, presented a brief overview of the development of an Interagency Pain Research Portfolio database. This database will contain information on Federally funded pain research grants, which were categorized by representatives from several NIH Institutes and Centers (ICs) and other Federal agencies with pain research portfolios, including the AHRQCDCDoDFDA, and VA. The database will complement a portfolio analysis report that the Office of Pain Policy is developing for release in early 2014. It also will address mandates in the Affordable Care Act that require the Interagency Pain Research Coordinating Committee (IPRCC) to identify gaps and avoid redundancy in trans-Agency research efforts. The search features of the database and a demonstration of its current functionality were presented to the NIH Pain Consortium. The database is expected to be completed and available to the public in early 2014.

News: NIH Pain Consortium Comparative Effectiveness Research Submissions to the Patient Centered Outcomes Research Institute (PCORI) for Funding Consideration

Dr. Linda Porter summarized the discussions from a meeting between the NIH Pain Consortium Executive Committee (Drs. Briggs, Grady, Landis, Somerman, and Volkow) and Dr. Joe Selby, Executive Director, PCORI. At this meeting, Dr. Selby expressed interest in receiving proposals from the NIH Pain Consortium for PCORI’s Board of Governors to consider as areas of interest for potential funding. Dr. Josie Briggs, Director, NCCAM, provided background information on PCORnet, the National Patient-Centered Clinical Research Network. The NIH Pain Consortium representatives then developed five preliminary concepts on which to focus the proposals to PCORI, which will be reviewed by the consortium’s Executive Committee and the consortium representatives for submission in early 2014.  Once developed, the NIH Pain Consortium will present the proposal topics to the IPRCC for comment.   

Update: National Pain Strategy

Due to time constraints, the update on the progress of the National Pain Strategy was postponed until the next Pain Consortium meeting.