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NOT-NS-18-080  The NINDS, with other NIH Institutes and Centers participating in the HEAL (Helping to End Addiction Long-term) Initiative, intends to publish a Funding Opportunity Announcement (FOA) to solicit applications to discover and validate novel nonaddictive pain targets.

The focus of this FOA will be on the basic science discovery of targets in the peripheral nervous system, central nervous system, immune system or other tissues in the body that can be used to develop pain therapeutics that have minimal side effects and little to no abuse/addiction liability. Research that will be supported by this FOA must include rigorous validation studies to demonstrate the robustness of the target as a pain treatment target.  These studies should have the goal of definitively determining the utility of a potential target for future therapeutic and/or device development.

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.

This FOA is expected to be published in October 2018 with an expected application due date in November 2018.

Pain