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NOT-NS-18-074  The NINDS, with other NIH Institutes and Centers participating in the HEAL (Helping to End Addiction Long-term) Initiative, intends to publish a Funding Opportunity Announcement (FOA) to solicit applications for research on the analytical and clinical validation of biomarkers, biomarker signatures, and endpoints for pain indications. The goal of this FOA will be to support the analytical and clinical validation of candidate biomarkers for use in the discovery and development of non-opiate alternatives to the treatment of pain conditions using retrospective and/or prospective methods. This FOA assumes that: 1) a candidate biomarker has already been identified, 2) assay technology has already been developed, and 3) a working hypothesis regarding context of use is in place.