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NOT-NS-18-073 This Notice is part of the NIH Helping to End Addiction Long-Term (HEAL) Initiative, an aggressive, trans-agency effort to speed scientific solutions to stem the national opioid public health crisis.

The validation of a biological target for the treatment of pain, i.e. the proof of its suitability for treating a specific or group of pain disorders, is critical to the development of new nonaddictive therapeutics. Therefore, NINDS and other participating Institutes and Centers (ICs) are inviting investigators to submit administrative supplements to PA-18-591 to expand existing ongoing pain target discovery research to add rigorous multimethod validation studies, and ultimately provide the validation of the pain therapeutic target necessary to accelerate the development of non-addictive treatments. 

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