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Clinical Research: Constipation Sections
Author Biography
Currently Selected Section: Introduction
What is constipation?
Understanding the problem
Objective Measurement
Subjective Measurement
Measuring Components
Precipitating Factors
Therapeutic Comparisons
Research Questions
Conclusion




 

 

 

 

 

 

 

 

 

Chapter 3: Methods for Clinical Research in Constipation: Introduction
           

Constipation is a complaint of around 10% of the adult population in general, but nearer 20% of the elderly (Thompson and Heaton, 1980). It has also repeatedly been reported to be more common in women (Everhart et al., 1989). Idiopathic constipation can be a major health problem to which much specialist gastroenterological time is devoted. However, constipation can also be a source of distress in geriatric medicine (Wolfsen et al., 1993); and in palliative care—the author's own specialty—constipation causes a level of distress rivaling that due to pain (Dunlop, 1989; Holmes, 1989).

Click to see data on the impact of constipation.
Percentage of Patients Reporting Significant Distress from Specific Symptoms                                       (Holmes, 1989)
Symptom Distress scores in 50 Patients with Advanced Cancer                                                          (Dunlop, 1989)


Constipation is a concern of patients and their health care attendants well beyond the borders of gastroenterology. This chapter is intended particularly for those who do not specialize in the management of gut disorders. It focuses, not on the characterization of constipation as a disease entity, but rather on constipation's impact on the patient and the alleviation of that impact. The chapter addresses:

  • Methodological issues – Practical issues face anyone wishing to conduct research into constipation.
  • Quantity and quality of research – How the limited amount of research, which is at best of moderate quality, impacts study strategies.
  • Outstanding research questions – Many research questions remain inadequately addressed or not tackled at all.

The hope is that those who wish to rectify this situation might find some assistance from the contents of this chapter.


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