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Clinical Trials in TMD Sections
Author Bio
Introduction
The Biopsychosocial Model
Currently selected section: Designing Multicenter RCTs
Players in an RCT
Randomization
Trial Design Quality
TMD Case Definition
Endpoints and Outcome Measures
Blinding & Masking
Study Sample Size
Number and Nature of Interventions
Study Length and Follow up
Intent-to-treat Analyses and Sample Size
Compliance
Multicenter RCTs
Implementing RCTs: Practical Issues
Analysis of TMD Trials
Conclusions
Acknowledgments
Appendix A
Appendix B

 

Chapter 22: Clinical Trials in Temporomandibular: Designing Multicenter RCTs
          

Problem 3.1

Using data from the table below, which of the subsets of TMD patients is it feasible to use in a multicenter trial with two arms that requires 100 cases in each arm, if you want to complete data collection and follow in under 3 years?

Subset
Inclusion Criteria
Cases per year
A
TMD (any diagnosis)
600
B
TMD + any major psychiatric disorder (30% prevalence; Kight, et al., 1999)
180
C
TMD with disc displacement-no reduction (4% prevalence; Dworkin, et al., 1992)
24


Question 3.1.1

Selection ASubset A and Subset B
Selection BSubset B and Subset C
Selection CSubset A and Subset C
Selection DNone of the above



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