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Clinical Trials in TMD Sections
Author Bio
Introduction
Currently selected section: The Biopsychosocial Model
Designing Multicenter RCTs
Players in an RCT
Randomization
Trial Design Quality
TMD Case Definition
Endpoints and Outcome Measures
Blinding & Masking
Study Sample Size
Number and Nature of Interventions
Study Length and Follow up
Intent-to-treat Analyses and Sample Size
Compliance
Multicenter RCTs
Implementing RCTs: Practical Issues
Analysis of TMD Trials
Conclusions
Acknowledgments
Appendix A
Appendix B

 

Chapter 22: Clinical Trials in Temporomandibular: The Biopsychosocial Model
          

In summary, the biopsychosocial model reflects our growing understanding that illnesses and cures are indeed complex and interrelated. To understand how and when we get sick, or whether or not we will respond to treatment, a host of factors in addition to biologic processes must be considered.

The biopsychosocial model does not seek to compete with, let alone replace, scientifically derived biologic models or current clinical practices. Rather, the model is an integrative one, which conceives that biologic processes and environmental factors, in the broad sense, are equipotent for explaining not only illness but also responses to treatment.

Thus, no health problem is conceived of as either solely physical or mental--as simply biologic or psychologic. Instead of trying to force a particular patient onto one end or the other of a single psycho-versus-somatic continuum, the current thinking suggests that at least two axes be conceptualized (see Figure 2.2 below):

  • On one axis, each patient is located to reflect their physical status, i.e. masticatory muscle disorders, TMJ disc derangements, and inflammatory and degenerative TMJ disorders.
  • On a second axis, the subjective, symptomatic state of the person is described, reflecting psychological, emotional, or behavioral factor known to influence pain report and pain-related behavior, i.e. pain severity, parafunctional jaw behaviors, depression, somatization, and psychosocial function.
  • Figure 2.2 Biophysical Model
    Domains for Treatment Interventions
    Graphic depiction of biopsychosocial model, described in text.

    The implications for research into treatment should be obvious, for if multiple physical and psychosocial factors enter into the origin, exacerbation, and maintenance of the expression of TMD (see Figure 2.2 above), then exploration of effective treatments and more meaningful treatment outcome measures should be expanded to reflect the role of these multiple factors.

    The interaction of physical, behavioral, and psychosocial factors helps to explain the diverse and often bewildering expression of TMD signs and symptoms that clinicians observe. In addition, these multiple factors allow paradoxical appearing responses to single vs. combined treatment approaches and especially, to short- vs. long-term treatment outcomes.


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