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Clinical Trials in TMD Sections
Author Bio
Introduction
Currently selected section: The Biopsychosocial Model
Designing Multicenter RCTs
Players in an RCT
Randomization
Trial Design Quality
TMD Case Definition
Endpoints and Outcome Measures
Blinding & Masking
Study Sample Size
Number and Nature of Interventions
Study Length and Follow up
Intent-to-treat Analyses and Sample Size
Compliance
Multicenter RCTs
Implementing RCTs: Practical Issues
Analysis of TMD Trials
Conclusions
Acknowledgments
Appendix A
Appendix B

 

Chapter 22: Clinical Trials in Temporomandibular: The Biopsychosocial Model
          

A biopsychosocial model to aid in the design of research into TMD has been developed (Dworkin et al., 1992).

Figure 2.1 Biobehavioral Model of Pain
Graphic depiction of behavioral model of pain, described in text.

 

As illustrated in Figure 2.1 above, this model shows:

  • Physical changes altering physiologic processes -- whether from trauma, infection, inflammation, genetic error, or developmental disability - can give rise to signals transmitted via nociceptive pathways.
  • Such nociceptive signals come to the attention, or invoke, higher level information processing systems of perception, appraisal, and initiation of motor behavior.
  • This occurs in the context of the social milieu in which the person exists and becomes defined as a patient.

It is through these ongoing interactions between physical (e.g. pathophysiologic) changes and the subjective awareness of them that symptoms emerge into consciousness and behaviors are undertaken to eliminate or ameliorate the aversive symptom state.

Thus, underlying the pain as a symptom are complex neurologic and neurochemical processes that yield nociceptive input to higher centers which, in turn, are interpreted as pain. If persistent, observable chronic pain behaviors emerge, including:

  • Anxious and depressive behaviors
  • Reporting of multiple symptom complaints including multiple pain complaints
  • Avoidance of social interaction
  • Treatment and medication seeking

As a chronic pain condition, TMD is no exception to this clinical picture and abundant evidence has established the presence of psychological distress and psychosocial disability as well as increased health care utilization in important segments of the TMD clinical population (Kight et al., 1999; Dworkin and Suvinen, 1998).

 

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