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Because often a number
of model systems are being studied to investigate aspects of a
disease, additional consideration needs to be given to the assessment
of similarities and differences between related human pain models,
including applicable animal model systems. Because pain in animals
is inferred from behavioral responses (see below), comparisons
of human and animal model systems have obvious limitations. Nevertheless,
these comparisons can be productive insofar as the gained understanding
can be complimentary or confirmatory.
| Table
16.1: Behavioral Pain Indices in Animal Models
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1.
Vocalization threshold in response to pressure applied
to the inflamed region
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2.
Struggle threshold in response to limb extension
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3.
Excessive grooming behaivor of affected body part
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4.
Limb withdrawal thresholds in response to various
stimuli (e.g. hot plate, electrical shock)
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