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With respect to a
particular taxonomic system (A, B, C), an estimate of the internal
validity is gained from contrasting the symptom report with the
level of expression of the corresponding clinical sign. This contrast
could include comparisons of the report of pain with clinical
measures of pain sensitivity or in-sensitivity, or the report
of limited range of motion with measures of such function. Mismatch
between symptom report and the corresponding clinical sign represents
an indication of questionable internal validity for that particular
diagnostic taxonomy.
| Figure
12.1: Level 1 of Model Validation Process |
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| Development
of a reference standard for model validation is
based on the clinical description of the disease
in question. A, B, and C represent case definitions
according to prevailing diagnostic taxonomies.
Internal validation is obtained by contrasting
symptoms described by patients with clinically
measured data of the associated phenomenon.
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