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Human Experimental Pain Models
Author Bios
Learning Objectives
Clinical Significance and Phenomenology
Complex Diseases: Need to Simplify
Model Requirements
Brief and Sustained Experimental Pain
Choice of the Pain Stimulus
A Model Design for Pain Experimentation
Experiential Adjustment
Choice of Stimulation Site
Currently selected section: Stimulation Site for a Study of TMJD
Experimental Design
Model Validation: Level 1
Model Validation: Level 2
Model Validation: Level 3
Model Validation: An Example
Cross-Validation with Other Model Systems
Model Systems as Tools
Sample Size Estimation
Potential Difficulties
Conclusion

 

Stimulation Site for a Study of TMJD
        

Question 10.1

Since response behaviors vary with the site of pain, experimental pain should be induced in the anatomical domain and target tissue implicated in the clinical disease.

Selection True
Selection False

Question 10.2

Feedback from subjects is used to control the stimulus magnitude in order to achieve an experientially-adjusted state of pain, such as pain of a given pain intensity.

Selection True
Selection False

Question 10.3

Pain-related affect is an unwanted by-product of experimental pain.

Selection True
Selection False

Question 10.4

The site of pain stimulation is chosen on the basis of experimental convenience.

Selection True
Selection False

Question 10.5

Reaching and maintaining a given pain intensity using feedback from subjects requires different stimulation intensities.

Selection True
Selection False

 

Subjects differ in the extent to which they activate pro-nociceptive and anti-nociceptive pathways. For this reason, a noxious stimulus of a given magnitude results in very different pain experiences by different subjects. On the other hand, if subject feedback is used to reach and maintain a given level of pain intensity, stimulation magnitudes differ from subject to subject. Pain-sensitive persons require less stimulation than pain-insensitive subjects to reach and maintain a similar intensity of pain. Pain affect is an important component of the pain experience that is often neglected in experimental studies.

 

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