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Several
generations of analgesic researchers have come to consensus
on approaches to single-dose analgesic studies. Because
the studies of other symptoms may share some of the same
challenges, palliative care researchers may benefit from
a familiarity with this analgesic study design literature.
However, many clinical research problems in pain and other
symptoms have received rather little study, including optimizing
the sensitivity of symptom-based measures, combination studies,
and the choice of control groups in repeated dose studies.
The solution to many of these problems may be facilitated
by frequent discussions among clinical researchers working
in different symptom areas.
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