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Trial Design: Pain Sections
Author Bio
Introduction
Placebo Effects
Single Dose Trials
Repeated Dose Trials
Explanatory Versus Pragmatic
Currently selected section: Dose-Response
Parallel Group Versus Crossover
Conclusion
 

 

Chapter 1: Clinical Trials of Pain Treatment: Dose-Response; Relative Potency; Combinations

 
           

Question 6.2.2

Figure 6.2 Pain Reduction vs. Dose and Plasma Concentration of Tricyclic Antidepressants in Post-Herpetic Neuralgia
Graphic depiction of Pain reduction vs. dose and plasma concentration of amitriptyline, described in text.

Assuming that there is actually a modestly significant positive dose- or concentration-response relationship in this study, did the individual titration of patients’ doses tend to strengthen or weaken it?


Selection A
 STRENGTHEN            Selection B WEAKEN


Page 33 of 52
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