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Trial Design: Pain Sections
Author Bio
Introduction
Placebo Effects
Single Dose Trials
Repeated Dose Trials
Explanatory Versus Pragmatic
Currently selected section: Dose-Response
Parallel Group Versus Crossover
Conclusion
 

 

Chapter 1: Clinical Trials of Pain Treatment: Dose-Response; Relative Potency; Combinations

 
           


Problem 6.5

Figure 6.5: Graphic depiction showing that Drug S enhances opioid analgesia in a potentially useful manner, described in text.

An analgesic research study claims that a clinical trial shows that Drug S enhances opioid analgesia in a potentially useful manner. Figure 6.5 shows the level of pain relief produced in postoperative patients by single oral doses of placebo; Drug S, 10 mg; morphine, 30 mg; and the combination of morphine, 30 mg, and Drug S, 10 mg. The combination produced significantly more analgesia than morphine, 30 mg, alone. Sedation, the main side effect of all active treatments, was significantly greater in the combination group than in the morphine group.

Question 6.5

Does this data suggest that Drug S will be a useful additive to morphine?

Selection AYes

Selection BNo

Selection CCannot say without more data (Specify what data.)

 

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