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Trial Design: Pain Sections
Author Bio
Introduction
Placebo Effects
Single Dose Trials
Repeated Dose Trials
Explanatory Versus Pragmatic
Currently selected section: Dose-Response
Parallel Group Versus Crossover
Conclusion
 

 

Chapter 1: Clinical Trials of Pain Treatment: Dose-Response; Relative Potency; Combinations

 
           

Question 6.4.4

Sustained release drug
Morphine
Fentanyl
Ending dose, mean (sustained release med only)
200 mg/day
40 mcg/hr
Average pain, 100 mm VAS
42
43
Rescue doses/24 hrs
1.4
1.4

The conversion ratio used to begin the switch from morphine to fentanyl will affect the final ratio of drug doses consumed.

True               False

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