| |
Question
6.4.3
|
Sustained
release drug
|
Morphine
|
Fentanyl
|
|---|
|
Ending
dose, mean (sustained release med only)
|
200
mg/day
|
40
mcg/hr
|
|
Average
pain, 100 mm VAS
|
42
|
43
|
|
Rescue
doses/24 hrs
|
1.4
|
1.4
|
|
Note
that patients were treated with morphine during the study
screening period and during the first part of the morphine/fentanyl
relative potency study. If patients develop tolerance to
morphine that does not extend completely to other opioids,
this "incomplete cross-tolerance" effect will tend to lower
the required dose of the second opioid, fentanyl and make
it appear more potent.
 
|