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Trial Design: Pain Sections
Author Bio
Introduction
Placebo Effects
Single Dose Trials
Repeated Dose Trials
Explanatory Versus Pragmatic
Currently selected section: Dose-Response
Parallel Group Versus Crossover
Conclusion
 

 

Chapter 1: Clinical Trials of Pain Treatment: Dose-Response; Relative Potency; Combinations

 
         

Question 6.3.2

Now assume that the investigator had a little more money and had been able to test two doses of Drug R, 5 and 10 mg, and morphine, 7.5 mg. Three different sets of results are plotted on each of the graphs below.

Click on image to enlarge

Figure 6.3.5: The high and low doses of Drug R produce 70% and 30% pain relief, respectively. In panel A, morphine produced 20% pain relief. In panel B, morphine produced 45% pain relief. In panel C, morphine produced 90% pain relief.

Which of these graphs allows the most reliable estimate of the relative analgesic potency of Drug R to morphine?

PANEL A PANEL B PANEL C

Answer

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