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Trial Design: Pain Sections
Author Bio
Introduction
Placebo Effects
Single Dose Trials
Repeated Dose Trials
Currently selected section: Explanatory Versus Pragmatic
Dose-Response
Parallel Group Versus Crossover
Conclusion
 

Chapter 1: Clinical Trials of Pain Treatment: Explanatory Versus Pragmatic
 
     
Problem 5.2
Dosage and monitoring
A moderate dose is selected based on preliminary human data to minimize the number of patients who encounter adverse effects and drop out. Patients are followed as they would be in a clinical practice by office visits and written instructions.
 
EXPLANATORY                                     PRAGMATIC
 

Patients are individually titrated to the highest dose they can tolerate before side effects reach hazardous levels. A study nurse calls them daily to adjust the medication.

 
EXPLANATORY                                   PRAGMATIC
 
Answer
 
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